Ultraviolet-Driven Deamination of Cytidine Ribonucleotides Under Planetary Conditions
نویسندگان
چکیده
منابع مشابه
Cytidine deamination induced HIV-1 drug resistance.
The HIV-1 Vif protein is essential for overcoming the antiviral activity of DNA-editing apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3) cytidine deaminases. We show that naturally occurring HIV-1 Vif point mutants with suboptimal anti-APOBEC3G activity induce the appearance of proviruses with lamivudine (3TC) drug resistance-associated mutations before any drug exposure....
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The human cytidine deaminase APOBEC3G edits both nascent human immunodeficiency virus (HIV) and murine leukemia virus (MLV) reverse transcripts, resulting in loss of infectivity. The HIV Vif protein is able to protect both viruses from this innate restriction to infection. Here, we demonstrate that a number of other APOBEC family members from both humans and rodents can mediate anti-HIV effects...
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It is well known that the high and characteristic absorption of nucleic acids in ultraviolet light is due to the absorption of their purine and pyrimidine components. Several workers have measured the absorption curves of the aminoand oxypurines (l-3) and Jordan has obtained similar data for adenosine and guanosine and for the corresponding nucleotides (3). In the latter instances substitution ...
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Environmental stresses such as deficit irrigation and ultraviolet radiation can influence plant growth and development. Among the environmental variables, ultraviolet radiation is an important factor in plant response to other stresses, such as deficit irrigation. The purpose of this study was to investigate the effects of ultraviolet B radiation (UV-B), irrigation stress and combined effects o...
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Deamination of 5-methylcytidine (5MeC) in DNA results in a G:T mismatch unlike cytidine (C) deamination which gives rise to a G:U pair. Deamination of C was generally considered to arise spontaneously. It is now clear that human APOBEC3A (A3A), a polynucleotide cytidine deaminase (PCD) with specificity for single stranded DNA, can extensively deaminate human nuclear DNA. It is shown here that A...
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ژورنال
عنوان ژورنال: Astrobiology
سال: 2020
ISSN: 1531-1074,1557-8070
DOI: 10.1089/ast.2019.2182